Anatomy, Histologyو Embryology
Rahim Golmohammadi; mohammadreza Mohajeri; Motahareh Golmohammadi
Volume 25, Issue 3 , July and August 2018, , Pages 271-278
Abstract
AbstractBackground and purpose: The effect of the marker expression high molecular weight cytokeratin ) HMWCK ( in Benign prostatic hyperplasia (BPH) and adenocarcinoma prostate. There were conventional reported about rate expression HMWCK in adenocarcinoma prostate The purpose of this studied was to ...
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AbstractBackground and purpose: The effect of the marker expression high molecular weight cytokeratin ) HMWCK ( in Benign prostatic hyperplasia (BPH) and adenocarcinoma prostate. There were conventional reported about rate expression HMWCK in adenocarcinoma prostate The purpose of this studied was to determine expression of the marker HMWCK with histopathological parameters in BPH and adnocarcinoma in prostatic by immunohistochemistry methods. Materials and Methods: This descriptive analytical research was conducted on 79 patients admitted to Hospital in Isfahan Iran. Samples were fixed in formalin and tissue processing and stained by hematoxilin and eosin adenocarcinoma samples were classified with Gleason pattern ( score) method by two pathologist. The effect of over expression in marker expression HMWCK was done after diagnosis by two expert(blind). The obtained data were analyzed using chi-square test.Results: Out of the 79 specimens 43 samples were BPH and 36 samples were adenocarcinoma . in 40 samples with diagnosis BPH were observed of the marker HMWCK and 3 samples were negative. Out of 36 samples with diagnosis adenocarcinoma 35 them over expression marker of the HMWCK were negative but one samples was positive. . The over specimens malignancy were in higher Gleason score There was significant relationships between type samples (BPH and adenocarcinoma) with over expression of the marker HMWCK P
MR MOHAJERI; R GOLMOHAMMADI; SM ZARGARIAN
Volume 14, Issue 3 , September and October 2007, , Pages 141-146
Abstract
Background and purpose: Genetic damages and dietary habits play important parts in colorectal cancer (CRC). p53 protein, a product of p53 gene, is the most important tumor suppressor.
The rate of p53 mutation and expression has been variously reported across anatomical regions. p53 protein has a short ...
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Background and purpose: Genetic damages and dietary habits play important parts in colorectal cancer (CRC). p53 protein, a product of p53 gene, is the most important tumor suppressor.
The rate of p53 mutation and expression has been variously reported across anatomical regions. p53 protein has a short half-life which tends to increase with mutation and is likely to be traced by immunohistochemistry. This study is intended to determine the p53 protein stability by pathological parameters across different areas in CRC.
Methods and Materials: This descriptive analytical research was conducted on 80 CRC cases admitted to Hospital in Isfahan, Iran from 2003 to 2007. p53 expression was detected by immunohistochemical methods in the samples after fixation, tissue processing and antigen retrieval. The obtained data were analyzed using chi-square.
Results: of the 80 specimens investigated, p53 protein stability was observed in 27 specimens (34%). No significant relationships were observed between p53 protein stability and tumor staging, differentiation and anatomical regions (colon and rectum) but the relationship between protein stability and mutation was significant.
Conclusion: p53 protein stability was observed in many mutated samples. Therefore, p53 protein detection in Cancer cases can be considered an important symptom of mutation signifying the prognosis and progress of cancer.